The Cyberneum is a newly developed, state-of-the-art Virtual Reality (VR) research facility equipped with several sophisticated VR systems that are providing unique opportunities to study human perception and human-machine interactions. The main areas of research in the Cyberneum relate to self-motion perception, spatial cognition, multiuser interactions, multisensory integration, and cybernetics as it relates to perception and action. In each of these areas it is important to both understand the processes underlying human sensory/motor perception under the most natural conditions, while at the same time maintaining precise experimental control. Rapid developments in multimodal VR technologies are now providing the tools necessary to create realistic, highly controlled experimental conditions. Using such tools we are able to effectively evaluate questions driven by basic science as well as investigate applied research questions in a precise and ecologically valid manner.