Oxidized phospholipids as targets in inflammatory pain in rodents

  • Datum: 19.11.2019
  • Uhrzeit: 11:15 - 12:15
  • Vortragende(r): Beatrice Oehler
  • King's College London
  • Ort: Max Planck House
  • Raum: Lecture Hall
  • Gastgeber: Hamid Noori
Oxidized phospholipids as targets in inflammatory pain in rodents

Dr Beatrice Oehler is a Clinician Scientist, trained in Anaesthesiology. In her research she focusses on the impact of oxidized phospholipids on pain perception and their potential as targets for novel analgesics. In the laboratory of Prof. Stephen McMahon, at King’s College London, she has expanded her broad expertise with in vitro calcium imaging of cultured cells, becoming highly skilled with in vivo calcium imaging of rodent dorsal root ganglion neurons in situ. In her talk she will give an overview of a pharmacological approach to study pain in rodents highlighting the advantages and disadvantages of calcium imaging techniques for gauging neuronal activity in vivo. She will introduce the ‘classical’ methods, emphasising the role of oxidized phosphatidylcholines as pro-nociceptive compounds, before presenting data obtained by calcium imaging in mice with inflammatory pain.

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